Franz Worek Selected Research

Acetylcholinesterase

12/2022	Pro: Oximes should be used routinely in organophosphate poisoning.
1/2022	Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense.
4/2020	Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react.
1/2020	Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning.
1/2019	New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
1/2019	Evaluation of the accuracy of "ChE check mobile" in measurement of acetylcholinesterase in pesticide poisoning.
12/2018	Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.
3/2017	Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6.
11/2016	Oximes in organophosphate poisoning: 60 years of hope and despair.
2/2016	Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report.

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Franz Worek Research Topics

Disease

80	Poisoning 12/2022 - 01/2003
20	Organophosphate Poisoning 12/2022 - 10/2005
4	Respiratory Insufficiency (Respiratory Failure) 01/2019 - 09/2007
2	Seizures (Absence Seizure) 04/2020 - 11/2018
2	Necrosis 09/2018 - 02/2016
2	Inflammation (Inflammations) 09/2018 - 02/2016
2	Blister (Bulla) 01/2018 - 11/2016
2	Bradycardia 02/2016 - 01/2003
2	Shock 04/2012 - 10/2005
2	Disease Progression 09/2009 - 10/2005
1	Edema (Dropsy) 01/2022
1	Pneumonia (Pneumonitis) 01/2022
1	Asthma (Bronchial Asthma) 01/2019
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2019
1	Wounds and Injuries (Trauma) 01/2019
1	Pain (Aches) 09/2018
1	Paralysis (Palsy) 09/2018
1	Neoplasms (Cancer) 09/2018
1	Erythema 01/2018
1	Ganglion Cysts (Ganglion) 01/2018
1	Myasthenia Gravis 08/2017
1	Alzheimer Disease (Alzheimer's Disease) 08/2017
1	Sialorrhea 02/2016
1	Hypotension (Low Blood Pressure) 02/2016
1	Miosis 02/2016
1	Burns 12/2013

Drug/Important Bio-Agent (IBA)

37	OximesIBA 12/2022 - 10/2005
33	Nerve AgentsIBA 11/2020 - 12/2005
26	AcetylcholinesteraseIBA 12/2022 - 12/2005
25	Organophosphorus CompoundsIBA 12/2022 - 12/2005
18	Atropine FDA LinkGeneric 01/2020 - 01/2003
13	PesticidesIBA 04/2020 - 04/2007
13	Cholinergic Agents (Cholinergics)IBA 04/2020 - 01/2003
9	Obidoxime Chloride (Obidoxime)IBA 01/2020 - 09/2009
8	EnzymesIBA 04/2020 - 04/2007
7	pralidoxime (Protopam Chloride)FDA Link 04/2020 - 06/2009
7	Dimethoate (Rogor)IBA 01/2020 - 10/2005
7	AntidotesIBA 02/2016 - 04/2007
6	SomanIBA 01/2019 - 04/2007
5	InsecticidesIBA 01/2020 - 10/2005
5	Chemical Warfare AgentsIBA 11/2019 - 04/2007
5	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 01/2015
5	Mustard Gas (Sulfur Mustard)IBA 01/2019 - 12/2013
4	asoxime chloride (H16)IBA 01/2020 - 09/2011
4	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 06/2019 - 09/2016
4	CarbamatesIBA 01/2019 - 07/2006
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 04/2008
4	MB327IBA 01/2019 - 02/2016
4	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019 - 01/2015
3	OrganophosphatesIBA 01/2017 - 12/2010
3	VX (EDIM)IBA 10/2016 - 09/2011
3	Parathion (Ethyl Parathion)IBA 09/2010 - 01/2003
2	PoisonsIBA 12/2022 - 06/2010
2	Cholinesterases (Cholinesterase)IBA 04/2020 - 12/2011
2	profenofosIBA 01/2020 - 09/2010
2	N,N'- monomethylenebis(pyridiniumaldoxime)IBA 01/2020 - 12/2010
2	Trimedoxime (Trimedoxime Bromide)IBA 01/2020 - 08/2013
2	AlbuminsIBA 01/2019 - 09/2018
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2018
2	Cholinergic ReceptorsIBA 09/2018 - 01/2017
2	Interleukin-6 (Interleukin 6)IBA 09/2018 - 02/2016
2	Human Serum Albumin FDA LinkGeneric 02/2018 - 10/2016
2	SarinIBA 01/2018 - 11/2016
2	Pharmaceutical PreparationsIBA 03/2016 - 12/2013
2	Therapeutic UsesIBA 01/2015 - 04/2007
2	Muscarinic AntagonistsIBA 12/2010 - 05/2010
2	methyl demetonIBA 09/2010 - 09/2009
2	Chlorpyrifos (Lorsban)IBA 06/2009 - 10/2005
1	HydrolasesIBA 01/2020
1	2-(2'-pyridyldithio)benzyldiazoacetateIBA 01/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020
1	Methyl Parathion (Dalf)IBA 01/2020
1	Aryldialkylphosphatase (Paraoxonase)IBA 01/2020
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2019
1	Propofol (Diprivan)FDA LinkGeneric 01/2019
1	Thiopental (Pentothal)FDA Link 01/2019
1	ButyrylcholinesteraseIBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 09/2018
1	Ibuprofen (Motrin)FDA LinkGeneric 09/2018
1	GlucocorticoidsIBA 09/2018
1	Cytostatic AgentsIBA 09/2018
1	Diclofenac (SR 38)FDA LinkGeneric 09/2018
1	MicroRNAs (MicroRNA)IBA 09/2018
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 09/2018
1	EsterasesIBA 09/2018
1	SaltsIBA 01/2018
1	Alkylating AgentsIBA 01/2018
1	lewisiteIBA 11/2016
1	4-(2-oxapentadeca-4-yne)phenylpropanoic acidIBA 02/2016
1	methamidophosIBA 02/2016
1	SolutionsIBA 01/2016
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015
1	methyl carbamateIBA 12/2013
1	Carbaryl (Sevin)IBA 12/2013
1	cyclohexanoneIBA 04/2012

Therapy/Procedure

19	Therapeutics 11/2020 - 12/2005
1	Artificial Respiration (Mechanical Ventilation) 04/2020
1	Drug Therapy (Chemotherapy) 09/2018
1	Debridement 12/2013
1	Lasers (Laser) 12/2013